Relationship of inhaled ipratropium and inhaled salbutamol with pupil dilation: A prospective observational study

This prospective randomized study aimed to compare the effects of nebulizer drugs on unilateral or bilateral dilation pupil that may develop due mask incompatibility patient in patients receiving inhaled therapy. Following approval local ethics committee, this was carried out prospectively and observationally period from October 1, 2018 April 2019 an emergency clinic with annual capacity 600,000 a tertiary education research hospital. The were divided into three groups: those given salbutamol alone (200 mcg), ipratropium (250 mcg/2ml), both ipratropium. diameters included measured twice using pupilometer device at hours 0 2 treatment. Ninety- one received inhaler treatment department study. process treatments indications not interrupted. Ipratropium (49.5%) used together 45 patients, 38 (41.7%), eight (8.8%). When absolute delta ratios compared, statistically significant difference observed between ipratropium, (p=0.001, 95% CI: 1.36-6.11 p<0.001, 1.51- 6.19, respectively). Salbutamol caused significantly greater diameter changes than other drugs. Although neurological diagnoses are considered anisocoria, it should be kept mind anisocoria also current being given.